Increased production and reduced urinary buffering of acid in uric acid stone formers is ameliorated by pioglitazone
نویسندگان
چکیده
منابع مشابه
High prevalence of uric acid calculi in diabetic stone formers.
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متن کاملUric acid stone disease.
The trend in uric acid stone formation appears to be on the rise again throughout much of the world. This is thought secondary to diet, body habitus, and social reasons. Uric acid stone disease has a rich and fascinating medical history and probably is the oldest known stone disease. Uric acid stone disease is strongly linked to the purine metabolic pathway, and its treatment is primarily medic...
متن کاملManagement of uric acid stone.
Uric acid stones are the most readily dissolvable of all types of urinary stones. By maintaining urinary pH between 6.2-6.8 with the use of sodium acid citrate or uralyt-U and reducing serum uric acid by allopurinol, we tried to dissolve 107 stones in 67 patients. Ninety three (86.9%) stones were dissolved and 6 (5.6%) passed spontaneously within a period of one year. Eight (7.5%) stones were r...
متن کاملThe diurnal variation in urine acidification differs between normal individuals and uric acid stone formers
Many biological functions follow circadian rhythms driven by internal and external cues that synchronize and coordinate organ physiology to diurnal changes in the environment and behavior. Urinary acid-base parameters follow diurnal patterns and it is thought these changes are due to periodic surges in gastric acid secretion. Abnormal urine pH is a risk factor for specific types of nephrolithia...
متن کاملA comparison of the metabolic profiles of diabetic and non-diabetic uric acid stone formers.
INTRODUCTION The aim of this study was to compare the metabolic profiles of diabetic and non-diabetic patients with uric acid stones to understand whether preventive strategies should be tailored to reflect different causative factors. METHODS The results of the metabolic evaluation of patients with uric acid stones identified prospectively from the Metabolic Stone Clinic at St. Joseph's Hosp...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2019
ISSN: 0085-2538
DOI: 10.1016/j.kint.2018.11.024